Electric field induced DNA damage: an open door for selective mutations.
نویسندگان
چکیده
Intense electric fields activate the mutagenic mechanism of a single guanine-cytosine base pair. Would they be able to induce a permanent mutation in real DNA? This question is addressed here by modeling a DNA-embedded fragment with state-of-the-art theoretical tools. We show how DNA can, in principle, be mutated if an appropriate electric field is applied.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 69 شماره
صفحات -
تاریخ انتشار 2013